This section presents the latest mouse data from our laboratory, including specimens from five organs: heart, liver, brain, lung, and kidney. It also encompasses glycoproteomics data from mice with Alzheimer's Disease (AD), Parkinson's Disease (PD), and normal controls. This significantly expands the depth and breadth of N-glycoproteomics characterization.
We manually integrated previous laboratory data to present site-specific N-glycoproteome data for three
common species: human, mouse and yeast.
A total of 103,047 glycoforms, 7,847 glycoproteins, 16,048 N-glycosites for human, and 269,603 glycoforms,
11,788 glycoproteins, 35,714 glycosites for mouse can be queried from literatures.
Combing the results in this study and that from literatures, a total of 331,145 glycoforms, 41,081
glycosites and 12,076 glycoproteins for mouse were exhibited on the website.
We have also provided preliminary biological insights into various diseases or physiological states based on
comparative N-glycoproteomics.
To our knowledge, this is the largest and most comprehensive database for mouse and human N-glycoproteome.
Users can upload a FASTA format proteome file (downloaded from Uniprot), and we will perform simulated enzymatic digestion according to specific rules. This generates our theoretical peptide library, which we will use for automated chart analysis from the perspectives of amino acids, peptides, and N-glycopeptides, providing better guidance for experiments.